713 The RNA-based reprogramming of renal epithelial cells derived from recessive dystrophic epidermolysis bullosa patients into induced pluripotent stem cells

Abstract

No effective therapies are available for recessive dystrophic epidermolysis bullosa (RDEB) at this time. Reprogramming adult cells into induced pluripotent stem cells (iPSCs) may allow for the development of new therapies for RDEB. iPSCs can be derived from many cell types, such as fibroblasts, keratinocytes, and blood cells. The isolation of fibroblasts and keratinocytes requires a skin biopsy, an invasive procedure commonly associated with scarring and inflammation, and venipuncture is potentially traumatic for RDEB patients due to the fragility of their skin.