712 Resection of non colorectal hepatic metastases: Long term results

Abstract

The aim of this multicentric retrospective study was to evaluate survival after resection of non colorectal hepatic metastases (HM). Patients and Methods —Between 1976 and 1990, 91 patients underwent resection of 60 synchronous and 31 metachronous non-colorectal and non-endocrine HM. The most common sites of the primary tumor (PT) were: stomach (n = 16), breast (n = 14), lung (n = 8) and exocrine pancreas (n = 7). The most common histopathologic types were adenocarcinoma (n = 42) and squamous cell carcinoma (n = 15). The surgical procedures were: 20 wedge resections and 71 radical hepatectomies. Results —Resection was curative in 77% of the patients. Operative mortality was 1%. There were seven biliary fistulas and 11 septic complications. Half of the patients underwent adjuvant chemotherapy Cumulative survival following curative resection was 54% at 1 year, 40% at 2 years, 32% at 3 years and 26% at 5 years. After palliative resection, survival was 33% at 1 year. Survival was not influenced by the time elapsed between resection of the PT and resection of the HM. There was no significant difference in survival between synchromous versus metachronous liver metastases, or according to the site of the PT. Wedge resection was as effective as lobectomy. Conclusions Surgical resection of HM in patients with PT other than colorectal cancer is advocated: postoperative morbidity and mortality are low; when resection is performed with curative intent, survival is similar to that obtained after resection of colorectal HM.