710 RELEVANCE OF SEMINAL PLASMA NITRIC OXIDE LEVELS AND THE EFFICACY OF SSRI TREATMENT ON PREMATURE EJACULATION

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research I1 Apr 2010710 RELEVANCE OF SEMINAL PLASMA NITRIC OXIDE LEVELS AND THE EFFICACY OF SSRI TREATMENT ON PREMATURE EJACULATION Sinan Levent Kirecci, Hakan Gurdal, Saban Mmimaroglu, Gokhan Gurbuz, Suzan Usanmaz, and Abdullah Simsek Sinan Levent KirecciSinan Levent Kirecci Istanbul, Turkey More articles by this author , Hakan GurdalHakan Gurdal Ankara, Turkey More articles by this author , Saban MmimarogluSaban Mmimaroglu Istanbul, Turkey More articles by this author , Gokhan GurbuzGokhan Gurbuz Istanbul, Turkey More articles by this author , Suzan UsanmazSuzan Usanmaz Ankara, Turkey More articles by this author , and Abdullah SimsekAbdullah Simsek Istanbul, Turkey More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1151AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of the present study was to determine the relevance of seminal plasma nitric oxide levels and the efficacy of selective serotonine reuptake inhibitors (SSRI) treatment on premature ejaculation. METHODS Sixteen married man (aged 20-50) with lifelong premature ejaculation (intravaginal ejaculation latency time-IELT less than 1 minute) and eleven healthy man (control group) were included in this study. Diabetes mellitus, Heavy smokers, Chronic disorders, Erectile dysfunction were excluded. All patient were evaluated history, physical examination, International Index of Erectile Function (IIEF) score and intravaginal ejaculation latency time by stopwatch method. Nitric oxide levels were measured by based on Griess reaction ( Navarro method ) and all seminal plasma samples were frozen et -80° C. Patients were randomly categorized 3 group to receive Paroxetine 20 mg/day (Group-1), sertraline 50 mg/day (Group-2) and healthy control (Group-3) for 4 weeks. Baseline and posttreatment findings were compared between the three groups. RESULTS Mean baseline seminal plasma nitric oxide levels in men with premature ejaculation were significantly higher than healthy control group ( 32.24 – 19.71,respectively). At the end of 1st month, Paroxetine, sertraline, groups mean IELT scores showed a significant improvement from the baseline values (p < 0.001, p = 0. 03, respectively). Baseline and 1st month follow up mean IIEF scores were 24,20 and 22,70 (p < 0.05); 23,40 and 23,72 (p > 0.05) in sertraline and paroxetine groups, respectively. After treatment of paroxetine and sertraline, NOx levels were decreased from baseline. Paroxetine leads to a significant decrease in NOx levels (p<0.05), whereas sertraline seems to have less of an effect on it (p= 0.882). CONCLUSIONS Our study indicates that premature ejaculation is significantly related with a higher level of seminal plasma NOx. Baseline seminal plasma NOx values in patients with premature ejaculation were obtained significantly higher than healthy control group After treatment with SSRIs decreased seminal NO may retard ejaculation. Further studies are needed to confirm this suggestion and role of NO in pathophysiology and treatment of premature ejaculation. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e277 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sinan Levent Kirecci Istanbul, Turkey More articles by this author Hakan Gurdal Ankara, Turkey More articles by this author Saban Mmimaroglu Istanbul, Turkey More articles by this author Gokhan Gurbuz Istanbul, Turkey More articles by this author Suzan Usanmaz Ankara, Turkey More articles by this author Abdullah Simsek Istanbul, Turkey More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...