Abstract
Phosphomonoesters (PME-mainly phosphoethanolamine), and phosphodiester + phospholipid bilayers (PDE + PB) can be quantified noninvasively using phosphorus MRS. Spectra from the livers of 7 normal infants (gest'n 27-40w, age 3-76d), and the brains of 12 other normal infants (gest'n 37-42w, age 1-14d) were obtained by MRS, using phase modulated rotating frame imaging (PMRFI) for spatial localisation. Global metabolite ratios relative to adenosine triphosphate (ATP) are shown with comparable data from adults. Liver and brain have more PME (p<0.001), and liver has less PDE + PB (p<0.02), in the infant than in the adult: Depth resolved PMRFI data show high PME/ATP at all depths in infant brain and liver. PDE+PB does not increase wich depth in the infant brain, unlike the fully myelinated adult brain. The sum of PDE(mainly phospholipid breakdown products)and PB is reduced compared to adults in localised spectra of white matter (p<0.01)
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