71 IDENTIFICATION OF TWIST, A BHLH TRANSCRIPTION FACTOR, HIGHLY EXPRESSED IN HUMAN MEDULLOBLASTOMA AND CHARACTERIZATION OF AN IN VITRO MODEL TO EXAMINE POTENTIAL INTERACTIONS WITH SONIC HEDGEHOG SIGNALING

Abstract

BackgroundTWIST (TW), a bHLH transcription factor with an uninvestigated role in medulloblastoma (MB), has important roles in human cancer and development. Normal cerebellar granule cell precursor development requires sonic hedgehog...