Abstract
Triplex-forming oligonucleotides (TFOs) bind DNA in a sequence- specific manner at polypurine/polypyrimidine sites and mediate targeted genome modification. Triplexes are formed by either pyrimidine TFOs, which bind parallel to the purine strand of the duplex (pyrimidine, parallel motif), or purine TFOs, which bind in an anti-parallel orientation (purine, anti-parallel motif). Initial studies demonstrated the ability of TFOs in both motifs to deliver mutagenic agents in a DNA site-specific manner.
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