7049 DUNNIGAN LIPODYSTROPHY AND SUCCESSFUL USE OF AID WITH U200

Abstract

Abstract Disclosure: T. Kader: None. S. Seltzer: None. A. williams: None. Our patient is a 60 year old female with dunnigans partiallipodystrophy diagnosed after her niece was diagnosed and was sent to genetics; She was found to have a mutation in LMNA geneand had a heterozygous sequence variant.She was diagnosed with partial lipodystrophy and had macrovascular complications including carotid stenosis requiring surgical intervention.She was treated originally with insulin pump therapy that was sensor augmented along with glp1 agonist and sglt2 inhibitor but she developed recurrent pancreatitis and glp1 agonist was stopped. The pancreatitis was not induced by hypertriglycidemia as her levels were normal.Since then she had poorly controlled diabetes with a1c 8.7 percent and was having some hypoglycemia.;After consultation with the patient about off□ label use of AID pump technology for type 2 diabetes and off□ label use of u200 in AID pump she was willing to try and results were quite impressive with a1c falling close to 7 and time in range up to 70 percent with no lows. Her total insulin dosages were approximately 200 units q day but with u 200 she was changing every 2 days .Despite insulin resistance and dunnigan lipodystrophy this case exemplifies safety of u200 in AID pump in a patient with dunnigans lipodystrophy. It is the first of such report and more studies should be done using this technology in this rare group of patients with insulin resistance and poorly controlled diabetes. Presentation: 6/1/2024