704 Decomposing a deterministic path to hair follicle dermal niche formation: The intersection of two morphogen gradients

Abstract

Organ formation requires coordinating signals to time proliferation, specify cell fates, and shape tissue. Tracing these events and the signals that drive them remains a challenge, as intermediate states across many critical transitions are unresolvable over real time and space. Here, we designed a unique computational approach to decompose a non-linear differentiation process into biological meaningful components to resolve the signals and cell behaviors that drive a rapid transition during hair follicle dermal condensate genesis.