704 CHANGE IN CEREBRAL ACTIVITY IN SEXUAL AROUSAL STATE BY SELECTIVE SEROTONIN REUPTAKE INHIBITOR ADMINISTRATION TO PREMATURE EJACULATION PATIENT: AN ANALYSIS USING LORETA (LOW RESOLUTION BRAIN ELECTROMAGNETIC TOMOGRAPHY)

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research I1 Apr 2010704 CHANGE IN CEREBRAL ACTIVITY IN SEXUAL AROUSAL STATE BY SELECTIVE SEROTONIN REUPTAKE INHIBITOR ADMINISTRATION TO PREMATURE EJACULATION PATIENT: AN ANALYSIS USING LORETA (LOW RESOLUTION BRAIN ELECTROMAGNETIC TOMOGRAPHY) Sung Chul Kam, Jae Hun Jung, and Jae Seog Hyun Sung Chul KamSung Chul Kam More articles by this author , Jae Hun JungJae Hun Jung More articles by this author , and Jae Seog HyunJae Seog Hyun More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1145AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To know the effects of serotonin reuptake inhibitor (SSRI) for the treatment of premature ejaculation (PE), changes of regional brain electrical activities by audiovisual erotic stimuli after sertraline administration were investigated utilizing three-dimensional electroencephalography (EEG) tomography. METHODS The eleven PE patients (36.9±7.8 yrs) and eleven male volunteers (24.2±1.9 yrs) were enrolled in this study. All recordings of EEG were done using international 10-20 system (23 channels). The EEGs were recorded during resting, watching a music-video, intermission and watching a porno-video before sertraline intake (control). EEG recordings were done 4 h after 50mg sertraline intake in the same order. Each segment was recorded for 10 min respectively. Five artifact-free segments with the average referential montage were selected. The LORETA images of cross-spectral analysis were obtained using the segments by LORETA-KEY software. Statistical nonparametric maps were obtained to detect the current density (CD) changes of high frequency bands between two EEG of control and 4 h after drug administration in each group. RESULTS Comparisons between control (before) and 4 h after drug intake in music video session of PE patients, the CD of beta-1 band were increased in Lt. fusiform gyrus and ligual gyrus. The CD of beta-2 band were decreased in Rt. superior temporal gyrus, inferior parietal lobule and precuneus. The CD of beta-3 band were increased in Rt. superior frontal gyrus and decreased in Rt. postcentral gyrus and fusiform gyrus. But comparisons between control and 4 h after drug intake in erotic video session of PE patients, the CD of beta-1 band were increased in Rt. middle temporal gyrus. And the CD of beta-3 band were increased in both superior frontal gyrus. Comparisons between PE patients and normal volunteers of 4 h after drug intake in erotic video session, the CD of beta-1 band were decreased in right middle temporal, superior temporal and middle occipital gyrus of PE patients. The CD of beta-2 band were decreased in Rt. middle occipital and lingual gyrus of PE patients. The CD of beta-3 band were decreased in Rt. middle and superior gyrus. CONCLUSIONS SSRI administration increased current source densities in both superior frontal and Rt. middle temporal gyrus in PE patients. It is suggested that SSRI acts on these particular cerebral regions and play an important role in the control of ejaculation on PE patients. Jinju, Republic of Korea© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e275 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sung Chul Kam More articles by this author Jae Hun Jung More articles by this author Jae Seog Hyun More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...