Abstract

Although solid organ transplantation science remains one of our most exciting medical frontiers, the maintenance of graft function through the induction of allograft tolerance and the prevention of graft rejection is of challenge. This is particularly relevant to survival of lung transplant recipients that considerably lag behind other solid organ recipients. We recently reported that priming the donor lung with human recombinant thioredoxin-1(Trx), a reactive oxygen species scavenger and redox regulatory protein, prior to transplant prevents activation of transcription factor nuclear factor kappa B (NF-kB) and prolongs allograft survival in a rat model of lung transplantation.

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