Abstract
The postprandial plasma amino acid patterns in infants fed a casein-or whey-predominant formula were assessed to determine the order of the limiting amino acids. Healthy fullterm infants were studied at birth, 1, 2, and 3 months of age. All infants were fed solely a casein or whey formula. At the first feed of the day, fasting, 1-, and 2-hr postprandial venous blood samples were obtained for the determination of plasma amino acids by standard automated techniques. The volume of milk consumed was determined by pre- and post-feeding weights of the infants using an electronic balance. Results of whey-fed infants expressed as change over baseline (Mean ± SD) are shown: Postprandial plasma tryptophan and cystine levels showed marked depressions at 3 months of age; plasma glycine levels fell persistently at 1 and 3 months of age. Thus, nonessential nitrogen and glycine may be limiting nutrients in infants fed a cow's milk whey-predominant formula.
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