701P Genomic alteration relationships with toxicity to TPF induction chemotherapy in head and neck squamous cell carcinoma patients participating in a clinical trial

A Olivares Hernandez,J.L García,N Alonso,L.A Corchete Sánchez,J Perez García,R Mesia Nin,J Rubió-Casadevall,C Garcia Giron,L Iglesias Docampo,A Carral Maseda,M Taberna Sanz,S Vazquez,A Gómez Muñoz,E Del Barco,R González Sarmiento,J.J Cruz Hernandez

doi:10.1016/j.annonc.2022.07.825

701P Genomic alteration relationships with toxicity to TPF induction chemotherapy in head and neck squamous cell carcinoma patients participating in a clinical trial

A Olivares Hernandez, J.L García + Show 14 more

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https://doi.org/10.1016/j.annonc.2022.07.825

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Journal: Annals of oncology : official journal of the European Society for Medical Oncology	Publication Date: Sep 1, 2022
License type: publisher-specific-oa

Affiliation: Institut Català d'Oncologia

#Neck Squamous Cell Carcinoma Patients #Head And Neck Squamous Cell Carcinoma + Show 8 more

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Abstract

The toxicity secondary to treatments with induction chemotherapy (ICT) with TPF (docetaxel, cisplatin and 5-fluorouracil) in head and neck squamous cell carcinoma (HNSCC) has important side effects. The standard treatment of locally advanced HNSCC is concurrent radiochemotherapy, with ICT relegated to exceptional cases. The objective of this research is to identify somatic genomic alterations associated with toxicity to TPF.

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