Abstract
Animal models of schizophrenia that present not only pathophysiology but also a wide array of symptoms affected in the patients are in an urgent need. Mounting evidence from human genetics studies indicate an involvement of gene networks related to NMDA receptor/CaMKIIa signaling. Recently, we generated a mouse line constitutively lacking CaMKIIa gene and reported a cellular feature, immature dentate gyrus (iDG), characterized by increased number of immature neuronal progenitors and a concomitant decrease in mature neurons in hippocampus. More importantly, iDG was detected in postmortem brains of a subset of schizophrenia and bipolar, raising a possibility that this cellular phenotype may present underlying pathophysiology of schizophrenia.
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