Abstract
Thioredoxin-interacting protein (TXNIP) is a multifunctional protein that regulates glucose metabolism and cellular redox state, the latter by binding and inhibiting the endogenous antioxidant thioredoxin. TXNIP is markedly upregulated by high glucose (HG) and we previously showed that STZ-induced diabetic TXNIP-/- mice are protected from developing features of diabetic nephropathy (DN). The pathogenesis of diabetes complications involves the oxidative inhibition of the glycolytic enzyme GAPDH, resulting in aberrant glucose metabolism.
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