7. THE EFFECT OF SLEEP DURATION ON SYSTOLIC PRESSURE AND NITRIC OXIDE CONCENTRATION IN HYPERTENSIVE PATIENTS

Abstract

Background: Poor blood pressure control of hypertensive patients is caused partially by bad lifestyle management, which increases the risk of a cardiovascular event by stimulating the defective endothelial function. Objective: This study aimed to investigate the effect of night sleep duration on systolic blood pressure and nitric oxide concentration in hypertensive patients. Methods: 60 hypertensive patients age >40 years based on the medical record participated in this study. The sleep duration and sleep quality were performed using the Pittsburgh Sleep Quality Index Questionnaire. The 40 participants thus selected randomly for the nitric oxide concentration assay using Nitric Oxide Salivary Elisa Kit ab65238. Results: 53 participants experienced night sleep duration ≤6 hours, and 44 (73.7%) participants had poor sleep quality. Night sleep duration was associated significantly with hypertensive patients’ systolic blood pressure (p = 0.000 < 0.05; Odds ratio = 0.008). Conclusion: A 1 % increase in night sleep duration can reduce systolic pressure by 0.11 % in hypertensive patients. There was no correlation between night sleep duration on nitric oxide concentration (p > 0.05). These findings provide evidence that night sleep duration is associated strongly with the increased systolic blood pressure but not directly caused by the alteration of endothelial function.