Abstract
This chapter discusses the properties of Nylon Microcapsules. Nylon 610, the most popular and perhaps the most extensively studied polyamide, is prepared by the interfacial polymerization reaction between 1,6-hexamethylenediamine (HMD) and sebacoyl chloride (SC). An attractive feature of the nylon polyamides is that slight monomer structural changes such as carbon chain length, addition of side chains, or cross-linking agents may alter the properties of the microcapsule wall. The wide range of drug diffusion rates from nylon microcapsules is reported as a function of the drug itself, the core material, and the properties of the nylon membrane. By encapsulating drugs in various matrix materials, drug release may be carefully controlled from the dense, free-flowing microcapsules. In addition to controlled-release, these microparticulates offer several other pharmaceutical advantages, including taste masking, separation of incompatible drugs, and improved drug stability. For nylon microcapsules to be useful as an oral delivery system, the stability of the membrane in gastrointestinal fluids must be characterized.
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