Abstract
In mitochondria of the squid, Loligo bleekeri, both the AGA and AGG codons are considered to correspond to serine instead of arginine as in the universal genetic code, and its genome encodes a single tRNA Ser gene with the anticodon GCT. Therefore, this gene product, tRNA SerGCU, should be able to translate all four AGN (N; U, C, A, and G) codons as serine. To elucidate this recognition mechanism, the tRNA SerGCU was isolated from squid liver and its complete nucleotide sequence determined. The tRNA SerGCU was found to possess 7-methylguanosine (m 7G) at the wobble position of the anticodon. This suggests that in the squid mitochondrial system, tRNA SerGCU with the anticodon m 7GCU can recognize not only the usual serine codons AGU and AGC, but also the unusual serine codons AGA and AGG, as in the case of starfish mitochondria (Matsuyama et al., J. Biol. Chem. 273 (1988) 3363–3368).
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
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