Abstract
Machine perfusion preservation has been used clinically and experimentally to extend the storage interval of donor hearts. However, the optimal preservation solution is not yet established. Utilizing glucose-supplemented Celsior preservation solution, we previously demonstrated that machine perfusion maintened donor heart metabolism during storage and led to superior reperfusion function but resulted in increased myocardial edema compared to conventional static preservation. We hypothesized that an alternative preservation solution, such as Unversity of Wisconsin Machine Perfusion Solution (UWMPS), that contains an interstitial impermeant (oncotic agent) might reduce graft edema while maintaining myocardial oxidative metabolism during long term storage.
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