Abstract
Publisher Summary This chapter discusses that Parkinson's disease, although in most respects a chronic, progressive disorder, can also be seen as a paroxysmal condition. Sudden, extreme, and occasionally unpredictable changes in disability are a characteristic feature of untreated and treated Parkinson's disease. A standard nomenclature for the different kinds of response swings seen in Parkinsonism is essential for a better understanding of the disease. The slowness and stiffness of Parkinson's disease are capable of modification with surprising ease. The converse of freezing, paradoxic kinesis usually occurs under the influence of strong emotion, stress, or fear. The enfeebled and immobile victim is suddenly able to walk or even run, although only for a brief period after which he or she sinks exhausted. Many aspects of parkinsonian disability, other than freezing, improve during the initial period of levodopa treatment.
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