Abstract
(±)-7-Deazacarbovir ( 2), which was conceived as an agent that could potentialy possess activity against both human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV), has been prepared in 3 steps from (±)-(3α,5α)-3-acetamido-5-(acetoxymethyl)cyclopentene ( 3) and 2-(2-amino-4,6-dichloropyrimidin-5-yl)acetaldehyde ( 4) in an overall yield of 36%. While non-cytotoxic, 2 was inactive towards inhibiting these target viruses as well as a variety of other viruses.
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