Abstract
7,8-Benzoflavone (7,8-BF), over a dose range of 0.1-10 microM, partially inhibited the synthesis of prostaglandin E2 (PGE2) in primary cultures of epidermal cells from SENCAR mice, and completely suppressed the TPA-dependent stimulation of PGE2 synthesis. Under identical conditions 7,8-BF also partially suppressed ornithine decarboxylase (ODC) activity in both unstimulated and TPA stimulated cultures. The finding that 7,8-BF inhibition of TPA-induced ODC can not be overcome by addition of exogenous PGE2 suggests that ODC induction by TPA involves a prostaglandin-independent component.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
