Abstract
Genetic aspects in migraine including vestibular migraine were reviewed. Migraine is one of the representative primary headache disorders, however, its pathophysiology still remains to be clarified. Concerning migraine, there are some genome-wide association studies. In such studies, at a total of 12 loci, significant association with migraine susceptibility has been identified. Most of them are related to synaptic function. In familial hemiplegic migraine (FHM), one of the specific types of migraine, mutated genes have been identified. Episodic ataxia may suggest the need for genetic studies in vestibular migraine or migraine-associated vertigo, because some types of EA, EA2 and EA3, show episodic vertigo and migraine. Interestingly, the mutated gene in EA2 is CACNA1A, which is the same as in FHM1. Probably, genes related to ion channels, which will affect synaptic functions, play an important role in migraine including vestibular migraine. Vestibular migraine and Menière's disease may have some common aspects from the viewpoint of channelopathy.
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