Abstract
AbstractA series of guanine 7‐nucleosides and their analogs modified in the sugar portion have been synthesized and evaluated for their cytotoxicity in vitro against five cancer cell lines (T98G,U‐251 MG, HeLa, SKOV‐3, T‐47D) with MRC‐5 (healthy cells) as a reference. Several guanine 7‐pentafuranosides and 7‐acyclo‐nucleosides have demonstrated a selective anti‐malignant potency at micromolar concentrations in the case of T98G and U‐251 MG glioma lines, while being totally inactive against other cancer cells.
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