Abstract
Oral squamous cell carcinoma (OSCC) is one of the most common types of cancer and its main etiological factors are smoking, alcohol consumption and HPV infection. OSCC metabolic profile is heterogeneous and related to mutations in several tumor suppressor genes and oncogenes. Patterns have become apparent, such as increased choline metabolism, which indicates active proliferation. Phosphatidylcholine (PC) is a key component of membranes and source of signaling molecules. The project aimed to analyze the glycerophospholipid profile in OSCC patients compared with control samples using mass spectrometry and gene expression techniques to analyze blood, tissue and clinical-pathological characteristics.
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