Abstract
693 Blocking negative effects of senescence in human skin fibroblasts with a plant extract
Highlights
Epithelial precursor cell-conditioned media ameliorates UV irradiation-induced extracellular matrix damage in human skin equivalents D Kim1,2, H Kim3, S Sohn3, A Kim3, S Baek3, C Lee3, I Jeong1 and T Kim3,2 1 Dermatology, Bundang CHA General Hospital, Seongnam-si, Korea, 2 Skin Biology Research Center, Seongnai-Si, Korea and 3 Biochemistry, CHA University, Seongnam-Si, Korea Human skins protect their physiological and structural integrities from various insults such as UVB-irradiation (UV-IR)
We examined whether epithelial precursor cellconditioned media (EPCs-CM) supplementation attenuates UVB-mediated skin photo-aging and regulate UVB-induced ERK signaling on dermal fibroblasts and 3-dimentional human skin equivalents (3D HSE). 3D HSE has been used with the aim of analyzing regenerative photo-protection after UV exposure
Modulation of ERK signaling by EPCs-CM treatment are examined in DFs and 3D HSE exposed to UVB-IR Our current studies show that UVB-IR up-regulates the expression of MMP-1 and decreases the level of procollagen-1 in primary human dermal fibroblasts respectably
Summary
Epithelial precursor cell-conditioned media ameliorates UV irradiation-induced extracellular matrix damage in human skin equivalents D Kim1,2, H Kim3, S Sohn3, A Kim3, S Baek3, C Lee3, I Jeong1 and T Kim3,2 1 Dermatology, Bundang CHA General Hospital, Seongnam-si, Korea (the Republic of), 2 Skin Biology Research Center, Seongnai-Si, Korea (the Republic of) and 3 Biochemistry, CHA University, Seongnam-Si, Korea (the Republic of) Human skins protect their physiological and structural integrities from various insults such as UVB-irradiation (UV-IR). We examined whether EPCs-CM supplementation attenuates UVB-mediated skin photo-aging and regulate UVB-induced ERK signaling on dermal fibroblasts and 3-dimentional human skin equivalents (3D HSE).
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