(692) - Surfactant Phospholipids as a Marker of Chronic Lung Allograft Dysfunction: A Targeted Lipidomics Approach

Abstract

Lung transplantation is and established treatment option for end stage lung disease, although long-term clinical outcomes are halted by the onset of bronchiolitis obliterans syndrome and chronic lung allograft dysfunction (CLAD). To date diagnosis of CLAD relies on pulmonary function tests. No biologic marker has yet been clearly established to corroborate or anticipate the diagnosis. We sought to investigate role of broncho-alveolar surfactant phospholipids as a marker of CLAD by using a targeted lipidomic methodology.