Abstract
Aim of the study is to evaluate prognostic value of DNA ploidy in the group of 106 pts with intraductal invasive adenocarcinoma in stage pT1–2 NO MO and with the Bloom grade II. All pts have been treated by surgery alone. Follow-up was at least 10 years (10–24). Clinical material was subdivided into 2 groups: A-without, B-with dissemination. DNA content was measured by image cytometry. There were 4 types of ploidy: diploidy and low, medium and high grade of aneuploidy. There were significantly higher rate of diploid tumours in the group A (83% vs 17%) and aneuploid tumours in the group B (67% vs 33%). The risk of dissemination was 17% for diploid and 54%, 74%, 100% respectively for aneuploid ones. Among patients with diploidy 83% had 10-years DFS, while nobody from the group of high grade of aneuploidy survive 10 years. The results suggest that high grade aneuploidy is a significant risk factor for dissemination in node-negative breast cancer patients.
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