Abstract
Measurement of gliadin antibodies (IgA and IgG) have been advocated for the screening and follow up of Celiac disease (J Pediatr 1983, 102:655, J Pediatr Gastro Nutr 1984; 3:205). We measured IgA and IgG gliadin antibody by ELISA in 26 age matched non atopic, non allergic controls, and disease controls including Crohn's, ulcerative colitis and cystic fibrosis (CF) patients. Children undergoing D-xylose absorption tests (5 gm. p.o.) for investigation of malabsorption were prospectively studied for IgA and IgG gliadin antibodies during a 12 month period. The data was analyzed for IgA and IgG gliadin antibody levels, diagnosis, age and D-xylose values.Conclusions: 1) IgA and IgG-GA are raised in 100% of active Celiacs. 2) IgA-GA are more specific than IgG-GA. 3) These elevations appear non-specific. 4) Xylose absorption correlated poorly with IgA and IgG-GA.
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