Abstract
count were significantly higher in Group II, III (7,950±1,523/mm3 vs. 24,672±1,087/mm3 vs. 24,720±820/mm3, p<0.05, 282±37/mm3 vs. 2,505±338/mm3 vs. 2,490±250/mm3, p=0.01). The minimal luminal diameter at 4 weeks was larger in Group III than Group I, II(2.24±0.34 mm vs. 1.61±0.50mm vs. 3.46±0.21 mm, p<0.05). The neointimal area was significantly smaller in Group III than Group I, II (7.41±0.95 mm2 vs. 11.42±2.05 mm2 vs. 3.68±1.55 mm2, p <0.05). The change of LVEDD and LVESD was significantly lower in Group III (LVEDD; 3.8±5.3 mm vs. 3.5±3.8 mm vs. -4.2±1.1 mm, p <0.05, LVESD; 2.4±4.2 mm vs. 2.3±5.1 mm vs. -3.4±2.6 mm, p <0.05) but the change of LVEF was significantly higher in Group III (1.8±4.2% vs. 2.1±1.3% vs. 7.1±0.9%, p <0.05). STAT-3, phosphorylated STAT-3, and VEGF were over-expressed in neointima and myocardium of group II and III compared with those of group I. Conclusions: Stem cell mobilization using G-CSF improve left ventricular ejection fraction, prevents remodeling but aggravates ISR in bare stents. The VEGF and STAT-3 have important role in prevention of LV remodeling and development of ISR by G-CSF.
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