687: The association between previous ectopic pregnancy and long-term neurological morbidity of the offspring

Abstract

Recent studies have demonstrated an association between ectopic pregnancy and preterm delivery in the subsequent pregnancies, though less is known about long-term neurological morbidity of the offspring. The purpose of this study was to examine the association between a history of ectopic pregnancy and long-term neurological morbidity of the offspring in the subsequent pregnancies. A population-based cohort analysis was performed including all singleton deliveries between the years 1991-2014 at a tertiary medical center. The primary exposure was defined as delivering an infant to a mother with a history of previous ectopic pregnancy. The main outcome evaluated was long-term neurological morbidity of the offspring up to the age of 18 years. Neurological morbidity included hospitalizations involving a predefined set of ICD9 codes, as recorded in hospital records. A Kaplan-Meier survival curve was used to compare cumulative neurological morbidity incidence. A cox proportional hazards model was conducted to control for confounders. : During the study period, 242,342 mothers met the inclusion criteria; 1,415 mothers had previous ectopic pregnancy of which 25.7% (n=364) were treated non-surgically, and 74.3% (n=1051) were treated surgically. Long-term neurological morbidity was comparable between groups (Table). Likewise, the Kaplan-Meier survival curve did not demonstrate a significantly higher cumulative incidence of neurological morbidity in offspring of mothers with a history of previous ectopic pregnancy, regardless the choice of treatment (log-rank test p= 0.555, Figure). In the Cox regression model, while controlling for confounders such as maternal age, preterm birth, maternal diabetes mellites, and hypertensive disorders, delivery of a neonate to mother with a history of previous ectopic pregnancy was not found to be independently associated with long-term neurological morbidity of offspring. Offspring of mothers with a history of ectopic pregnancy are not at an increased risk for long-term neurological morbidity.View Large Image Figure ViewerDownload Hi-res image Download (PPT)