Abstract
Melanoma, an aggressive malignancy of melanocytes, is responsible for more deaths than any other skin cancer. We have developed an in vivo murine model of melanomagenesis in which benign pigmented lesions progress to become invasive melanomas. The polyaromatic hydrocarbon DMBA (7,12-dimethylbenz(a)anthracene) was applied to the skin of C3H/HeN mice followed by repeated exposure to phorbol 12-myristate 13-acetate (TPA). This treatment produces a specific activating mutation in the H-ras oncogene, resulting in a single amino acid substitution (leucine for glutamine) at the 61st residue.
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