Abstract
To investigate the effects of PM2.5 on A375 human melanoma cells and the possible mechanism. The PM2.5of winter haze was collected in Beijing. A375 was treated with different concentrations of PM2.5 suspensions. The morphology of A375 cells was observed by microscopy. The number of viable A375 decreased and the cells lost their normal shape gradually with the treatment of PM2.5. PM2.5 also inhibits the A375 cells viability and induces blockage of S phase.The protein expression of CDk1 and CyclinE1 were significantly decreased after PM2.5 treatment.
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