674P Initial curative management for localized/locally advanced head and neck squamous cell carcinomas (LAHNSCC): Exclusive (chemo)radiation (CRT) or S/IC (surgery or induction chemotherapy) – The EPOCKS study

J Fayette,J Leval,P Zrounba,D Girodet,J.M Prades,C Dalban,P Manipoud,D Cellier,M Burgy,G Thibault,E Reyt,P Ceruse,S Racadot,P Muller,I.L Ray-Coquard,S Chabaud,M Poupart

doi:10.1016/j.annonc.2022.07.798

674P Initial curative management for localized/locally advanced head and neck squamous cell carcinomas (LAHNSCC): Exclusive (chemo)radiation (CRT) or S/IC (surgery or induction chemotherapy) – The EPOCKS study

J Fayette, J Leval + Show 15 more

https://doi.org/10.1016/j.annonc.2022.07.798

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Journal: Annals of Oncology	Publication Date: Sep 1, 2022
License type: cc-by

Affiliation: Clinique Charcot, Cancer Research Center of Lyon, Hôpital Nord, Centre Léon Bérard, Centre Hospitalier Métropole Savoie, Institut de Cancérologie Strasbourg, Centre Hospitalier Universitaire de Grenoble, Hospices Civils de Lyon

#Chemo)radiation #Role Of Induction Chemotherapy + Show 8 more

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Abstract

The initial curative standard therapy for LAHNSCC by exclusive CRT or surgery (+/- CRT) have similar results in term of PFS and OS. Indication depends on several factors including regional expertise and anticipated sequela. The role of induction chemotherapy (IC) remains questionable until today. Previous publications suggested that surgery followed by CRT could be relevant for high-risk relapse tumors. The aim of this retrospective study was to compare as first-intent curative treatment CRT to alternative approach (S/IC: surgery and/or IC +/- CRT).

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