Abstract

The differentiation between Spitz nevi (SN), Atypical Spitzoid neoplasms (ASN) and Spitzoid malignant melanomas (SMM) represents a challenge to dermatopathologists. ASN are lesions in the gray zone for which a definitive histopathologic diagnosis of benign or malignant cannot be made with absolute certainty. We sought to investigate whether the major epigenetic biomarker, 5-hydroxymethylcytosine (5-hmC), is differentially expressed and can aid in the diagnosis of benign and malignant Spitzoid neoplasms.

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