Abstract
Cutaneous lupus erythematosus (CLE) is a chronic autoimmune disease that disproportionately impacts patients with skin of color. Metabolic reprogramming plays a critical role in modulating the innate and adaptive immune response, but its role in cutaneous autoimmune conditions, like CLE, is less well studied. Thus, untargeted liquid chromatography-mass spectrometry metabolomics was performed to characterize the skin and serum of CLE patients. Eleven CLE patients (8 Black and 2 Hispanic Whites) and 14 normal controls were recruited from outpatient dermatology clinics at the University of Texas Southwestern Medical Center and Parkland Health and Hospital System in Dallas, TX.
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