#6713 THE INTERACTION EFFECT OF PHASE ANGLE AND AGE ON FEMORAL NECK BONE MINERAL DENSITY IN PATIENTS WITH NON-DIALYSIS CHRONIC KIDNEY DISEASE STAGE 5

Abstract

Abstract Background and Aims Low bone mass is common in malnourished patients with chronic kidney disease (CKD) and can lead to higher risk of fractures. Elderly and CKD patients have the same risk factors for protein energy wasting, sarcopenia, and osteoporosis. We attempted to investigate an association between phase angle (PhA) and bone mineral density (BMD) in dialysis naïve patients with stage 5 CKD, and to identify a statistical relationship between PhA and age that affects bone density. Method Bio-impedance spectroscopy for evaluating body composition and PhA and dual energy X-ray absorptiometry for determining the BMD were simultaneously performed in 167 consecutive patients (age: 59.65 ± 13.98 years; women: 40.1%). Two-way analysis of variance (ANOVA) was conducted to assess the potential interaction effect of PhA and two age group (young and elderly group) on femoral neck BMD (FN-BMD). Results Our results showed that PhA and age were independently associated with both FN-BMD and the T-score in multiple linear regressions analyses. A significant interaction effect of PhA and age on FN-BMD was found in the two-way ANOVA (P = 0.028). Average BMD values for first and second tertiles of PhA were higher in the young group than the elderly group, whereas patients in the elderly group had higher BMD in third tertiles on average. Conclusion A relationship between PhA and BMD in patients with advanced-stage CKD was identified in current study. The effect of PhA level on FN-BMD was different between elderly and young patients. Higher PhA levels may have protective effects on bone health in the elderly patients with stage 5 CKD and seem to be an important determinant for BMD.