671 Acid Suppression Results in Increased Expression of Gastrin-Positive Cells in Duodenal Lamina Propria of Mice With Targeted Deletion of Men1 and Somatostatin Gene Loci

Abstract

higher in CA when compared with CD ( P=0.013) and SG (P=0.037). GPR43 expression was significantly higher in the ileum compared with CA ( P<0.001), CT (P<0.001), CD (P= 0.001), and SG (P<0.001). This expression pattern was observed in all 5 patients that donated biopsies from 3 or more locations ( figure 2). Discussion and conclusion: This study in which biopsies from different intestinal locations were obtained within the same subject allowed us to profile SCFA receptor expression throughout the human ileum and colon. Gene expression of GPR41 and GPR43 was significantly higher in the ileum when compared with all parts of the colon. In addition, expression of GPR41 was significantly higher in the proximal part of the colon when compared with the distal colon. These findings might suggest that prebiotic fibers fermented in the ileum or proximal colon are most suitable for exerting beneficial health effects through GPR41 and GPR43 activation and downstream signaling in the human gastrointestinal tract.