67-OR

Abstract

Objectives The KDIGO 2012 criteria emphasize the independent role of glomerular filtration rate (GFR) and albuminuria to assess the prognosis of chronic kidney disease (CKD), as both relate independently to all-cause mortality and cardiovascular morbidity/mortality. In this study we want to determine the prevalence of CKD in women with a recent history of preeclampsia. Methods We included 602 primiparous women with a history of preeclampsia. They were all at least 4 months postpartum and had no history of pre-existent hypertension, diabetes or kidney disease. We estimated GFR by the CKD-epi-equation, and quantified urinary protein loss (micro-albuminuria: >3.0 mg/mmol creatinine; macro-albuminuria: proteinuria >300 mg/24 h). We categorized women on the basis of the KDIGO 2012 criteria. Results Median time postpartum was 9 (6–18) months. Table 1 shows the different GFR and albuminuria categories. 419 (70%) women had a normal GFR and no albuminuria. Based on the KDIGO guideline, 77 (13%) women with a moderately increased risk would require yearly monitoring, in over 85% of the cases because of excessive urinary protein loss. Only 21 (3.5%) women were classified to be at high risk and would require referral to a nephrologist for twice yearly monitoring. Conclusions Follow-up of kidney function is relevant for about 16% of all women with a history of preeclampsia. Kidney function should be part of cardiovascular risk assessment after preeclampsia, with special emphasis to be directed on the postpartum disappearance of the preeclampsia-induced albuminuria. Disclosures J. Spaan: None. V. Lopez van Balen: None. L. Peeters: None. M. Spaanderman: None.