668 Peyronie's Disease is common in poorly controlled diabetics but is not associated with the metabolic syndrome

Abstract

The root cause of Peyronie's disease (PD) is unknown. Many theories have been advocated for its etiology, but the most widely accepted is trauma to the tunica albuginea. Because prevalence varies widely, the potential for contributory cofactors/comorbidities has been proposed. We hypothesized that metabolic syndrome and other systemic comorbidities may be found at higher rates in the PD population, and endeavored the largest descriptive study ever to test this hypothesis. A retrospective chart review of 1833 patients presenting to a men's health clinic with a variety of complaints: erectile dysfunction (ED), premature ejaculation (PE), premarital checkup, small penis, decreased libido, lower urinary tract symptoms (LUTS) and PD were screened for PD. Variables collected: presence/absence of diabetes mellitus (DM), hypertension (HTN), dyslipidemia (DL), body mass index (BMI), total testosterone (T), penile peak systolic velocity (PSV), end diastolic velocity (EDV) in patients with ED and/or PD, smoking, glycosylated hemoglobin level (HbA1c) in patients with diabetes, and the presence of metabolic syndrome. Patients with PD were compared to patients without PD.