666P - Prognostic Significance of Metastatic Lymph Node Ratio in Patients with Gastric Cancer, an Evaluation in North-East of Iran

Abstract

ABSTRACT Aim: In this study we evaluated the prognostic impact of metastatic lymph node ratio (MLR) in patients with gastric cancer undergoing curative surgical resection. Methods: A total of 121 patients with gastric adenocarcinoma undergoing curative R0 surgical resection in our institutions between 2003 and 2010 were included in this study. MLR was classified into 3 groups as follows: MLR0; 0, MLR1; >0-0.33 and MLR2; 0.34-1. We used Kaplan-Meier method to calculate survival rates and log rank test to compare survival curves between groups. Cox proportional hazards model was utilized for multivariate analysis. Results: The median age of patients was 65 (range; 32 to 89) with a male to female ratio of 91/30 (3.03). 88 patients underwent total gastrectomy (72.5%) and 33 subtotal gastrectomy (27.5%). With a median total retrieved lymph node of 11 (range; 6 to 44), the MLR0 to MLR2 was calculated in 28(23.1%), 31(25.6%) and 62 (51.2%) patients respectively. MLR2 (>0.33) was significantly associated with higher Tumor stage (T1-T2: 18.7% vs. T3: 56.2%, p = 0.002). With a median follow up time of 12 months (range; 2-88), the 3-year survival in patients with MLR0, MLR1 and MLR2 was 75.1%, 54.8% and 9.5% respectively (p value Conclusions: MLR with cut off point of 0.33 can be used as an independent prognostic factor in gastric cancer patients undergoing curative surgical resection. This factor can effectively predict survival even in cases with insufficient ( Disclosure: All authors have declared no conflicts of interest.