Abstract

Atopic dermatitis (AD) is characterized by Staphylococcus aureus (SA) colonization, epithelial defects & type 2 immunity. Dupilumab (DPL), which blocks the biological actions of IL-4 & -13, provides an opportunity to probe the import of type 2 inflammation on microbial, epithelial & immune features of AD. To do this, the Atopic Dermatitis Research Network designed a 6wk, RDBPC trial with high density sampling (Days 0, 3, 7, 14, 21, 28 & 42) to quantify these changes & assess how they relate to disease severity (EASI, NRS, IGA & SCORAD).

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