Abstract
It has been suggested that anabolic-androgenic steroids such as testosterone promote body building in part because they reduce pain sensitivity. The present study was designed to determine whether male rats’ nociceptive and opioid antinociceptive sensitivity changed after chronic exposure to high-dose testosterone. Adult, gonadally intact Sprague-Dawley male rats were given once-daily injections of testosterone propionate (TP, 5 mg/kg s.c.) or safflower oil vehicle for 28 days. Beginning 3 hr after the vehicle or TP injection on day 28, latency to respond on two tests of acute thermal nociception (hotplate and tail withdrawal) and a test of acute mechanical nociception (paw pressure) was recorded, or behavior on a test of inflammatory nociception (formalin test) was recorded; in the latter group of rats, the development of thermal hyperalgesia and mechanical allodynia was also evaluated periodically for a month after formalin injection, during which daily vehicle or TP injections were continued.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
