Abstract
Senescence is the process by which cells irreversibly avoid dividing without undergoing cell death and enter a state of irreversible growth arrest. Fibroblast senescence associated with aging is known to contribute to the increased incidence of non-melanoma skin cancer in the aged population. To that end, agents that can inhibit fibroblast senescence could be protective. Senescence can be induced by various cellular stressors such as DNA damage, oncogenic activation and oxidative stress. Hydrogen peroxide (H2O2), ultraviolet light, tert-butyl hydroperoxide, and hyperoxia are pro-oxidative stressors which are used experimentally to induce premature senescence.
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