Abstract
Melanoma, the most lethal form of skin cancer, is rarely curable at its advanced stages. The early events of this disease, during which treatment would be beneficial, remain poorly elucidated. Melanocyte stem cells (McSCs) residing in the hair follicle niche were proposed to be cells-of-origin for melanoma. To understand the cellular and molecular mechanisms regulating the initiation and progression of McSC-derived melanoma, we established a novel c-Kit-CreER-driven melanoma mouse model that enabled us to specifically target McSCs and trace their oncogenic behaviors.
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