Abstract
Chronic autoimmune thyroiditis (CAT) is multifaced disease. Its incidence has increased dramatically over the past few decades afflicting up to 2% of the general population. CAT as autoimmune disorder results...
Highlights
Background and AimsFew studies are available on pulmonary function abnormalities in children with diabetes with controversial results
Its incidence has increased dramatically over the past few decades afflicting up to 2% of the general population
Pubertal disorders: delayed, or even precocious puberty are always present. Another intriguing form of dysfunction in Chronic autoimmune thyroiditis (CAT) could be the subclinical hypothyroidism with mixed signs of hypo and hyperfunction
Summary
Chronic autoimmune thyroiditis (CAT) is multifaced disease. Its incidence has increased dramatically over the past few decades afflicting up to 2% of the general population. Some children expirience all thyroid dysfunction types during natural course of the disease; mild hyperthyroidism at diagnosis (hashitoxicosis), euthyroid state, and gradual progression from subclinical to overt hypothyroidism. The clinical manifestations of acquired hypothyroidism (AH) in childhood differ from those in adults. The most important sign of AH in childhood is growth failure. Weight tends to increase and in most instances weight for age is greater than height for age. Pubertal disorders: delayed, or even precocious puberty are always present. Another intriguing form of dysfunction in CAT could be the subclinical hypothyroidism with mixed signs of hypo and hyperfunction (autoimmune dysthyroidism). The reasons for diagnostic pitfalls, because of clinical ambiguity are challenging for pediatricians and endocrinologists
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