662 Recurrent inflammatory diseases of the urogenital tract associated with cytomegalovirus infection

Abstract

ObjectiveRecurrent inflammatory diseases of urogenital tract (UGT) associated with CMVI and other viral infections is a difficult practical and scientific problem because of the often unpredictable answer of a pathologic process to the treatment. Late diagnosis and ineffective therapy of patients with CMVI and other viral diseases of UGT increase cases of infertility and reduce the quality of life of patients. Study design: 1037 patients, women between 19 to 49 years old (average age 29,02), complaining of itching, burning, discharge, redness, swelling of the vagina and labia, recurrent inflammatory process, burning and pain during urination underwent routine gynecological examination and smears for PCR test “Femoflor” from the cervix, vagina, urethra for detection of CMVI and microbe associations. Results: In 100 patients (9, 64%) the persistence of CMV infection on the mucous membrane of the cervix and urethra was revealed. Monoinfection was detected in 13 patients (13%) In 74 patients (74% )- a violation of the biocenosis of the UGT (Gardnerella spp.), Candida spp in 18 patients (18%), Chlamydia in 6 patients (6%), Ureaplasma spp in 53 patients (53%), M.hominis in 11 patients (11%), M.genatalium - 1 patient (1%), in 1 patient (1%) - Tr. vaginalis. 15% of smears showed LSIL, 1% HSIL, and in 1/3 cases of dysplasia - HPV -test (28 types) was negative. In 67%, the inflammatory process and reactive changes were diagnosed. In 3%, polyps of the cervical canal were detected, in 2% - polyps of the endometrium, that relapses after hysteroscopy and hormons. In 2% of cases was chronic urethritis with the no effectiveness of antibiotics. Conclusions: According to our results if there are clinical symptoms of infections of UGT, CMVI diagnosis is necessary in routine practice. To determine the CMV infection is preferable to study material from the cervical canal, vagina, urethra with DNA detection (PCR method).