Abstract
Aripiprazole is an atypical antipsychotic approved as an adjunct for inadequate response to antidepressants in the treatment of major depressive disorder. Addition of aripiprazole to escitalopram reverses the inhibitory actions of escitalopram on firing activity of serotonin (5-HT), norepinephrine (NE) and dopamine (DA) neurons. This study investigated the postsynaptic neurotransmission of the previously studied monoamines systems.
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