#6579 ANALYSIS OF RISK FACTORS FOR CUTANEOUS CALCIPHYLAXIS IN HEMODIALYSIS PATIENTS

Abstract

Abstract Background and Aims Risk factors with cutaneous calciphylaxis were analyzed in hemodialysis patients. Method Clinical data of hemodialysis patients who were diagnosed with cutaneous calciphylaxis and admitted to Sichuan University West China Hospital and hospitals in West China Nephrology Union were retrospectively collected. Noncalciphylaxis patients in hemodialysis center of West China Hospital Sichuan University were randomly selected as the controls. Group 1: The 1:1 matched cases and controls by age (year, within ±3) and duration of hemodialysis (month, within ±20%) as matching factors. Group 2: The controls were matched to cases in a 1:1 ratio by gender and duration of hemodialysis (month, within ±20%) as matching factors. Univariate and multivariate binary Logistic were used regression analysis model, screening for statistically significant variable factors. Results Most of cutaneous calciphylaxis patients were male and elderly. Group 1: The univariate regression analysis showed that gender, diabetes mellitus, coronary heart disease are significantly associated with calciphylaxis. Laboratory examination results showed that parathyriod hormone (PTH), serum albumin, serum phosphate, C reactive protein (CRP) were significantly with calciphylaxis. Diabetes mellitus, lower albumin, higher serum phosphate and higher CRP were independent risk factors after multivariate analysis. Group 2: The univariate logistic regression analysis showed that age, BMI, coronary heart disease, diabetes were significantly associated with calciphylaxis. Laboratory examination showed that alkaline phosphatase (ALP), PTH, serum albumin and CRP were all significantly associated with calciphylaxis. Diabetes mellitus, lower albumin, higher PTH, and higher CRP were independent risk factors after binary Logistic analysis. Conclusion Diabetes mellitus and higher CRP, higher PTH, higher serum phosphate, lower albumin, are important high risk factors.