656. EPIMIOLOGICAL ASPECTS OF PROGRESSION FROM BARRETT'S ESOPHAGUS IN DYSPLASIA AND ESOPHAGEAL ADENOCARCINOMA: LONG FOLLOW UP IN A HIGH VOLUME CENTER

Abstract

Abstract Barrett's Esophagus (BE) affects approximately 3 million people in Brazil and an increase in its incidence has been observed in recent years. Especially in scenarios with social and financial limitations, it is of fundamental importance to study the epidemiological factors related to a higher risk of progression from EB to dysplasia in our specific population to optimize these patients' follow-up. A retrospective analysis of patients with BE with long follow-up at Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, regarding epidemiological aspects associated with a higher incidence of BE progression to dysplasia and adenocarcinoma. Statistical analyzes were performed to establish correlations between the variables sex, age, smoking, ethnicity, BMI, Barrett's extension and the presence of esophageal dysplasia and adenocarcinoma. We found that sex, smoking, ethnicity and Barrett's extent are variables that are related to a higher incidence of adenocarcinoma. This study confirmed that males, smoking and white patients, besides patients with long Barrett's epythelium were associated with higher risk to develop dysplasia and adenocarcinoma.