Abstract
Ultraviolet (UV) radiation is a cause of skin cancer and aging and has been shown to affect a variety of biological phenomena. Whereas UV radiation can induce local hormones that affect melanin synthesis, the mechanisms by which UV radiation directly affects melanocyte biology and melanin synthesis, independent of DNA mutation, remain poorly understood. In this study, we examined the effects of UV radiation on melanosomal pH and metabolism in melanocytes and melanoma cells in vitro. We demonstrate that UV radiation elevates melanosomal pH in a soluble adenylyl cyclase (sAC) and reactive oxygen species (ROS) dependent manner.
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